Letrozole is a medication commonly used as an aromatase inhibitor to treat breast cancer in postmenopausal women. It works by decreasing the amount of estrogen produced in the body, which can slow or stop the growth of certain types of breast tumors. To learn more about Letrozole and its indications for use, visit Letrozole cost.
Clinical Indications of Letrozole
Letrozole is primarily indicated for the following medical conditions:
- Adjuvant Treatment: Letrozole is used as adjuvant therapy following surgery in postmenopausal women with hormone receptor-positive early breast cancer to reduce the risk of recurrence.
- Advanced Breast Cancer: It is indicated for the treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women who have previously received anti-estrogen therapy.
- Neoadjuvant Therapy: Letrozole can be utilized as a neoadjuvant treatment to shrink tumors before surgery, making the procedure more accessible and potentially less invasive.
- Prevention: In some cases, Letrozole is prescribed as a preventive measure in women at high risk of developing breast cancer.
Mechanism of Action
Letrozole functions by inhibiting the aromatase enzyme, responsible for converting androgens to estrogens. By lowering estrogen levels, Letrozole helps to hinder the growth of estrogen-sensitive tumors.
Conclusion
Letrozole plays a vital role in the management of breast cancer in postmenopausal women. Its applications range from curative treatment to prevention, highlighting its importance in oncology. Patients considering Letrozole should consult their healthcare provider to discuss the benefits and potential side effects.